Association of eNOS and STAT6 Gene Polymorphisms with the Susceptibility of Polycystic Ovary Syndrome in South Indian Women

Purpose: Polycystic Ovary Syndrome (PCOS) is a complex multifactorial endocrine metabolic disorder of reproductive-aged women characterized by hyperandrogenism, hirsutism, anovulation, hyperinsulinemia and polycystic ovaries. The main aim this study was to investigate the association eNOS STAT6 gene Single Nucleotide Polymorphisms (SNPs) with susceptibility PCOS in South Indian Women. Research question: What status SNPs PCOS? Methods: present genetic involves clinically confirmed patients (n = 105) non-PCOS controls 110) Dravidian linguistic group. Genotyping +894G/T (Glu298Asp) SNP 2964G/A performed Polymerase Chain Reaction (PCR) sequencing analysis. Results: There were statistically significant differences genotype allele frequencies eNOS+894G/T (p 0.1110) STAT62964G/A (0.0019) between cases controls, according codominant, dominant recessive models. Conclusion: In conclusion, polymorphisms may constitute an inheritable risk factor for women.